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KMID : 0379119950230030209
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Korean Journal of Mycology
1995 Volume.23 No. 3 p.209 ~ p.225
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The effects of carbon sources on antitumor and anticomplementary activities of Ganoderan extracted from the mycelium of Ganoderma lucidum IY009
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이준우/Lee, June Woo
정훈/한만덕/윤경하/정성균/이승룡/Jeong, Hoon/Han, Man Deuk/Yoon, Kyung Ha/Chung, Sung Kyun/Lee, Seung Yong
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Abstract
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Ganoderan, antitumor β-glucan from Ganoderma lucidum was extracted from the mycelium of G.lucidum IY009 which was cultured in various carbon sources. The mycelium was shown to be capable of utilizing various carbon sources, e.g., soluble starch, fructose and glucose, and differs in morphology on carbon sources. In radioisotope assay, about 5.2∼16% of glucose was to be incorporated in ganoderan of the mycelium. The monosugars of these ganoderan were mainly consisted of glucose, mannose, galactose. The galactose was not good carbon source for growing the mycelium but the best carbon source for producing the potentialized-ganoderan on the antitumor and anticomplementary activity. The tumor inhibition ratio of ganoderan-GAL, obtained from galactose medium, was 83.6% at the dose of 20 ㎎/㎏/day. This crude polysaccaride was composed of five monosaccharide and the protein contained 16 amino acids. Also, ganoderan-GAL increased the anticomplementary activity than that obtained from any other media. This fact suggests that the structural differences of ganoderan influence the antitumor and anticomplementary activity.
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KEYWORD
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